Mechanism resembling aging and cancer found in a Finnish mitochondrial disease

Morphological aberrations of CIII-deficient hepatocyte nuclei. a H&E-stained liver sections showing typical WT hepatocyte nuclei and the spectrum of aberrant Bcs1lp.S78G hepatocyte nuclei (anisokaryosis, karyomegaly, uneven nuclear envelope, atypical shapes,…

Cellular ‘cruise control’ system safeguards RNA levels in Rett syndrome nerve cells

Cis-acting elements in the 3ʹUTR are highly associated with half-life changes. a Random forest classifier for prediction of mRNA sequence features relevant for half-life fold-change in human NEURTT and in…

Clouds carry drug-resistant bacteria across distances: study

Atmospheric monitoring could help pinpoint the sources of drug-resistant bacteria found in clouds, researchers said. For a team of Canadian and French researchers, dark clouds on the horizon are potentially…

Mortality high for patients with concurrent TB, COVID-19

Patients with concurrent tuberculosis (TB) and COVID-19 have a high risk for death, according to a study published online April 26 in PLOS Global Public Health. Alice V. Easton, Ph.D.,…

What to know about tick, Lyme season following a mild winter

This undated photo provided by the U.S. Centers for Disease Control and Prevention (CDC) shows a blacklegged tick, which is also known as a deer tick. Ticks will be more…

Study finds inhaling ethanol can disable influenza A in mice

The study found that mice treated with ethanol vapor are protected from lethal respiratory infections caused by the influenza A virus. Credit: Dr. Miho Tamai and Prof. Hiroki Ishikawa (OIST)…

Two studies analyze natural killer cells as they tackle the worst form of malaria

Antibody-mediated NK cell activity in children: (A) Merozoite opsonizing antibodies from Junju adults (n=40) induced a significantly higher proportion of ab-NK cells degranulation compared to Junju children (n=293). Hyperimmune (PHIS)…

Study finds stool transplants more effective than antibiotics for treating recurring, life-threatening gut infections

Illustration of bacteria in the human gut. Credit: Darryl Leja, National Human Genome Research Institute, National Institutes of Health A new study, published in the Cochrane Database of Systematic Reviews…

Surgery is the most effective treatment for metabolic liver disease, says new study

Credit: CC0 Public Domain Metabolic (bariatric) surgery is more effective than medications and lifestyle interventions for the treatment of advanced non-alcoholic fatty liver disease. A new paper, published today in…

Study reveals mechanism by which a circadian clock molecule leads to lung fibrosis

Decreased REV-ERBα protein abundance and increased protein levels of COL1A1 and LOX in IPF lungs compared to healthy control. Healthy control and IPF formalin fixed-paraffin embedded (FFPE) lung samples were…