Summary: A new genetic study reveals that individuals with severe anorexia nervosa are nearly four times more likely to carry rare, damaging mutations in PLIN4, a gene primarily expressed in…
Tag: Genetics
Adults With ADHD Face Higher Long-Term Dementia Risk
Summary: A massive study of more than 187,000 older adults enrolled in the NIH’s All of Us Research Program reveals that adults with attention-deficit/hyperactivity disorder (ADHD) face more than quadruple…
Early DBS Protects Cognition in Genetic Parkinson’s
Summary: A multi-center international study reveals that the timing of Deep Brain Stimulation (DBS) surgery is the deciding factor in preserving cognitive function for Parkinson’s disease patients carrying a GBA1…
Cell Membrane Lipid Governs Retinal Light Sensitivity
Summary: Using cryogenic electron microscopy and synthetic model membranes, researchers have mapped how the membrane phospholipid PIP2 binds to cyclic nucleotide-gated (CNG) ion channels in retinal rod cells. Even at…
The Placenta May Decide Autism Vulnerability
Summary: A new study in mice reveals that maternal immune activation during a precise gestational window triggers autism-like developmental disruptions exclusively in male fetuses. Researchers traced this vulnerability to damaged…
Early Stress Heightens Adult Anxiety
Summary: Researchers uncovered a fundamental epigenetic mechanism explaining how early-life adversity permanently alters the brain’s stress response networks. The study identified that childhood trauma increases levels of the enzyme SETD7…
TRF2 Preserves Muscle Stem Cell Identity and Drive Repair
Summary: Researchers identified an unexpected dual function for the telomeric protein TRF2 in muscle tissue regeneration and stem cell preservation. The study demonstrates that TRF2 goes beyond its traditional role…
Alzheimer Genetic Risk Scores Do Not Explain SuperAging
Summary: A new study reveals that exceptional memory in older adults is not driven simply by low inherited Alzheimer’s disease risk. The multi-center study evaluated 142 SuperAgers (adults in their…
Recall-By-Genotype for Precision Psychiatry – Neuroscience News
Summary: A new study provides a practical framework for recall-by-genotype (RbG) research within large, diverse healthcare system biobanks to advance precision psychiatry. Researchers utilized Mount Sinai’s BioMe biobank to identify…
