Summary: Researchers uncovered a fundamental epigenetic mechanism explaining how early-life adversity permanently alters the brain’s stress response networks. The study identified that childhood trauma increases levels of the enzyme SETD7…
Tag: Genetics
TRF2 Preserves Muscle Stem Cell Identity and Drive Repair
Summary: Researchers identified an unexpected dual function for the telomeric protein TRF2 in muscle tissue regeneration and stem cell preservation. The study demonstrates that TRF2 goes beyond its traditional role…
Alzheimer Genetic Risk Scores Do Not Explain SuperAging
Summary: A new study reveals that exceptional memory in older adults is not driven simply by low inherited Alzheimer’s disease risk. The multi-center study evaluated 142 SuperAgers (adults in their…
Recall-By-Genotype for Precision Psychiatry – Neuroscience News
Summary: A new study provides a practical framework for recall-by-genotype (RbG) research within large, diverse healthcare system biobanks to advance precision psychiatry. Researchers utilized Mount Sinai’s BioMe biobank to identify…
Risk Genes for Borderline Personality Disorder Discovered
Summary: Researchers identified 11 independent genomic risk regions (loci) and 9 specific candidate genes linked to BPD development. The study establishes that common genetic variants account for 17.3% of the…
Gene Therapy Reverses Severe Traits of Fragile X Syndrome
Summary: Utilizing specialized adeno-associated viral (AAV) vectors to deliver functional human FMR1 directly into the central nervous system, the team successfully restored FMRP production within key cortical and subcortical regions…
Preconception Maternal Trauma Doubles Schizophrenia Risk
Summary: A new study demonstrated that women who endured Nazi persecution as young girls passed a significantly elevated risk of psychiatric illness to their children born decades after World War…
Network Mapping Uncovers 641 Hidden Schizophrenia Risk Genes
Summary: Researchers have revolutionized psychiatric genomics by identifying 641 previously unrecognized genes associated with schizophrenia. The study analyzed genetic datasets from over 102,000 individuals alongside postmortem brain tissue samples spanning…
74 Genetic Locations Linked to Anxiety Identified
Summary: The largest genome-wide association study (GWAS) on anxiety to date has mapped the complex polygenic architecture underlying worry and fear-based responses. The massive meta-analysis evaluated genomic data from 693,869…
