Summary: Supported by a $943,000 NIH grant, neuroscientists at the University of Central Florida are investigating how nicotine alters neuronal mitochondria within the nucleus accumbens. By examining the subcellular mechanisms…
Category: neurobiology
Disruption of Striatal D2 Receptor Neurons Drives ADHD and Impulsivity
Summary: Researchers have demonstrated that deleting the membrane-fusion protein NSF specifically from dopamine D2 receptor (D2R)-expressing neurons leads to striatal shrinkage, severe dopamine depletion, and classic ADHD-like hyperactivity and impulsivity…
Aging Brains Maintain Robust Language Networks Despite Cognitive Decline
Summary: While executive functions like memory and problem-solving naturally decline as we age, new brain imaging research reveals that the neural network responsible for language remains preserved and fully functional.…
Eye Tracking Reveals Where Human Reading and AI Processing Diverge
Summary: A new study evaluated whether large language models (LLMs) can accurately account for human reading dynamics. The team compared eye-tracking data from 368 adult readers against predictions generated by…
Prefrontal Cortex Can Block Creative Problem-Solving
Summary: Researchers discovered an unexpected role for the medial prefrontal cortex (mPFC), a region traditionally viewed as the executive driver of behavioral flexibility. The team demonstrated that the mPFC can…
Why Psychedelics Make Everything Feel Deeply Connected
Summary: Researchers introduce “apical hypercontextualisation”—a bottom-up neurobiological mechanism explaining how psychedelics (psilocybin, LSD, DMT, mescaline) transform perception and cognition. Moving beyond macro-scale whole-brain neuroimaging, the framework focuses on the cellular…
Receptor Density Shapes Whole-Brain Network Dynamics
Summary: Researchers developed a biologically grounded whole-brain computer model that bridges microscopic molecular chemistry with macroscopic neural activity. The team integrated detailed empirical maps of muscarinic acetylcholine receptor density across…
Early Stress Heightens Adult Anxiety
Summary: Researchers uncovered a fundamental epigenetic mechanism explaining how early-life adversity permanently alters the brain’s stress response networks. The study identified that childhood trauma increases levels of the enzyme SETD7…
