Summary: Alzheimer’s disease, traditionally seen as a brain-centric condition, may have systemic origins and can be accelerated through bone marrow transplants from donors with familial Alzheimer’s to healthy mice. A…
Tag: Genetics
Epigenetics is of critical importance in autoimmune-related skin diseases, says study
Credit: Lingyu Gao, Qianjin Lu The central dogma proposed that genetic information predominantly transfers from DNA to RNA during gene expression to make a functional product protein. This absolute theory…
New review on p53 biology and reactivation in blood cancers
A simplified scheme of p53 regulation in cells upon stress and the drugs currently evaluated in clinical trials for p53 reactivation for improved therapy in MDS and AML. Credit: Biomarker…
Scientists identify Achilles heel of lung cancer protein
Rendering of interface in the mutant EGFR studied that was shown to be critical for EGFR-driven tumor growth. The K946E mutation shown in red was used by the team to…
Molecular Alterations in Brain Tissue Provide Clues to Suicidal Ideation
Summary: Researchers have identified molecular alterations in the blood and brain tissues of individuals who committed suicide, offering new insights into susceptibility factors and therapeutic targets. The study analyzed genetic,…
Unlocking Synaptic Mysteries: The Role of FAM81A Protein
Summary: Researchers have identified a critical protein, FAM81A, that plays a pivotal role in forming postsynaptic protein agglomerations, essential for synaptic function in the brain. By analyzing 35 previous studies,…
For childhood cancer survivors, inherited genetic factors influence risk of cancers later in life
Credit: Unsplash/CC0 Public Domain Common inherited genetic factors that predict cancer risk in the general population may also predict elevated risk of new cancers among childhood cancer survivors, according to…
Large-scale study explores link between smoking and DNA changes across six racial and ethnic groups
Credit: CC0 Public Domain Smoking changes the way genes are expressed, which later contributes to the development of lung cancer and other smoking-related illnesses. But the link between epigenetics (the…
