CAR-NKT cells target tumor cells in vitro. a, Representative flow cytometry plots illustrating the purity of NKT cells isolated from the spleen of iVα14-Jα18 transgenic mice, n = 12 with similar results.…
Tag: Immunology
Researchers identify role of Parkinson’s-related protein in cancer and T cell activation
Credit: Journal of Clinical Investigation (2024). DOI: 10.1172/JCI180983 A team from the Wistar Institute has demonstrated the role of Parkin—a protein implicated in Parkinson’s disease—in the body’s innate immune response…
Long-term metastatic melanoma survival dramatically improves on immunotherapy, clinical trial finds
Credit: CC0 Public Domain Long-term data from a landmark international trial show about half of patients with metastatic melanoma treated with a combination of immune checkpoint inhibitors survive cancer-free for…
Study identifies five key factors that predict response of cancer patients to immunotherapy
Credit: Unsplash/CC0 Public Domain A team of researchers at IRB Barcelona has identified five independent factors that predict cancer patients’ response to checkpoint inhibitors (CPIs). The study, which has been…
Autoimmune disease researchers find immune cells escape therapy due to ‘exhausted’ state
by Frederike Buhse, Exzellenzcluster Präzisionsmedizin für chronische Entzündungserkrankungen Graphical abstract. Credit: Immunity (2024). DOI: 10.1016/j.immuni.2024.08.005 In autoimmune diseases, the immune system mistakenly attacks the body’s own structures. A research team…
Low cortisol and hair-trigger stress response in the brain may underlie long COVID, study finds
Credit: Pixabay/CC0 Public Domain Proteins left behind by COVID-19 long after initial infection can cause cortisol levels in the brain to plummet, inflame the nervous system and prime its immune…
Overcoming the limits of immunotherapies
Karl Petri (left) is setting up an Emmy Noether research group at the University Hospital of Würzburg with the support of the German Research Foundation. Alexandre Trubert (centre) and Leon…
Australia launches landmark peanut allergy treatment for babies
Credit: CC0 Public Domain Australian children with potentially deadly peanut allergies will be offered life-saving treatment in a nationwide program touted as a world first. Eligible babies will receive daily…
Research shows spike gene mutations do not correlate with increased SARS-CoV-2 variant severity
A visual representation of the novel in silico methodology used in the study: prediction of protein structure, molecular docking simulations, and statistical analysis of computational metrics. Credit: UNC Charlotte New…
Targeted drug treatment leads tumor cells to imitate viral infection, researchers discover
mIDH1 inhibition restores immune surveillance. Credit: Science (2024). DOI: 10.1126/science.adl6173 A number of cancers, including certain brain and liver tumors, as well as myeloid leukemias, are driven by mutations in…
