Distinct T-cell signatures observed at different stages of type 1 diabetes development

Credit: CC0 Public Domain A study conducted at the University of Eastern Finland found distinct signatures in CD8+ T cells in blood samples from children with newly diagnosed type 1…

Scientists create first mouse model with complete, functional human immune system

Left, malar rash in a (huNSGW41-derived) Lupus THX mouse (three weeks after pristane injection). Middle, serum antinuclear IgGs (scale bar, 20 μm) and kidney immunopathology (H&E and anti-huIgG immunofluorescence; scale bar,…

New insights into metabolic and immune pathway interactions in obesity

A diagrammatic illustration represents the proposed model. The energy sensor AMPK becomes less active under energy overload conditions, which leads to hypophosphorylation of TBC1D1. Hypophosphorylated TBC1D1 is more active and…

Scientists discover new T cells and genes related to immune disorders

A newly developed method called ReapTEC allowed the discovery of thouands of active bidirectional enhancers. Further anaylis of GWAS data revelaed that various immune-mediated diseases, like multipkle sclerosis and rheumatoisd…

New therapy strengthens the immune system’s counterattack on skin cancer

Stained electron micrograph of a T cell. Scientists have shown in laboratory experiments that they are able to create a large number of the T cells that are capable of…

Study suggests staying current with COVID-19 vaccinations helps combat emerging variants

A COVID-19 vaccine is prepped at an OHSU clinic. New research from OHSU reveals a strong immune response to an updated vaccine in the fall of 2023, suggesting a clear…

Researchers explore diagnostic role of the systemic inflammation index

Credit: Unsplash/CC0 Public Domain A routine blood test that measures a patient’s inflammation levels could improve the early diagnosis and management of a wide range of debilitating autoimmune diseases. The…

Researchers identify new way to inhibit immune cells that drive allergic asthma

Activation of ILC2s causes inflammation in mouse lungs (left), but this is reduced by treatment with Yoda1 to stimulate Piezo1 channels (right). Credit: (2024). DOI: 10.1084/jem.20231835 Researchers at the Keck…

Epigenetics is of critical importance in autoimmune-related skin diseases, says study

Credit: Lingyu Gao, Qianjin Lu The central dogma proposed that genetic information predominantly transfers from DNA to RNA during gene expression to make a functional product protein. This absolute theory…

Is your blood aging your brain? It might increase your dementia risk

Credit: Unsplash/CC0 Public Domain By 2050, the global population of adults 60 and older will approximately double, leading to upward of 153 million dementia cases. That’s why University College Cork…