An EM image with the corresponding NanoSIMS 13C map. Credit: Spataro et al 2023. DOI: 10.1186/s40478-023-01608-8 Parkinson’s disease is a complex neurodegenerative disorder that leads to the deterioration of specific…
Tag: Parkinson’s & Movement disorders
Researchers uncover ‘circular logic’ of RNAs in Parkinson’s disease
Scherzer and colleagues laser-captured neurons from 190 frozen postmortem human brain samples, including some non-neuronal cells for comparison. Then, they used ultra-deep, total RNA sequencing to study the exact sequences…
New insights into the protein-mediated motor neuron loss in amyotrophic lateral sclerosis
Using novel mouse ALS models, researchers discovered that the pathogenic TDP-43 exhibits distinct propagation patterns in the corticospinal pathway and spinal circuits, providing insights into the mechanisms underlying the progressive…
Potential ‘game-changer’ in diagnosing Parkinson’s disease
Credit: Unsplash/CC0 Public Domain A certain protein builds up in the brains of most Parkinson’s patients, a study confirmed on Thursday using a new technique hailed as a potential “game-changer”…
