Summary: DNA changes in umbilical cord blood may help predict which children are at higher risk for future health issues like diabetes, liver disease, and stroke. Researchers analyzed chemical tags on DNA, known as methylation patterns, and linked specific alterations to markers of metabolic dysfunction later in childhood.
Notably, changes in genes like TNS3, GNAS, and CSMD1 were tied to liver fat accumulation, high blood pressure, and abnormal waist-to-hip ratios. The study suggests that environmental factors during pregnancy may influence these early epigenetic signals.
Key Facts:
- Early Risk Markers: Changes in DNA methylation at birth were linked to metabolic issues years later.
- Gene Connections: Alterations in genes like TNS3 and GNAS were tied to liver fat and blood pressure problems.
- Preventive Potential: Early detection could lead to proactive interventions before disease develops.
Source: Digestive Disease Week
The umbilical cord may become a crystal ball of sorts, helping doctors predict the future of children at risk for long-term health problems, including diabetes, stroke, and liver disease.
DNA changes found in cord blood could offer early clues about which infants are at higher risk — opening the door to earlier and potentially life-saving interventions, according to research to be presented at Digestive Disease Week (DDW) 2025.
“We’re seeing kids develop metabolic problems earlier and earlier, which puts them at higher risk for serious complications as adults,” said lead author Ashley Jowell, MD, a resident physician in internal medicine at Duke University Health System.
“If we can identify that risk at birth, we may be able to prevent it.”
Researchers used a new genetic tool to analyze umbilical cord blood from 38 children enrolled in the Newborn Epigenetics Study, a long-term birth cohort study based in North Carolina. They looked for changes in chemical tags — called methyl groups — on the infants’ DNA that switch genes on or off.
When these switches occur in critical parts of the DNA, called imprint control regions, their effects can persist through fetal development and into later life.
The team compared the DNA changes to health data collected when the children were 7 to 12 years old — including body mass index, liver fat, an indication of liver inflammation or damage known as alanine transaminase (ALT), triglyceride levels, blood pressure, and waist-to-hip ratio.
They identified multiple regions of altered DNA associated with metabolic dysfunction later in childhood.
Changes in a gene called TNS3 were linked to liver fat, ALT, and waist-to-hip ratio, while alterations in others, including GNAS and CSMD1, were connected to blood pressure, waist-to-hip ratio, and ALT.
“These epigenetic signals are laid down during embryonic development, potentially influenced by environmental factors such as nutrition or maternal health during pregnancy,” said co-author Cynthia Moylan, MD, associate professor of medicine, division of gastroenterology, at Duke University Health System.
“If validated in larger studies, this could open the door to new screening tools and early interventions for at-risk children.”
While the sample size was small, the researchers say the findings are promising and warrant further investigation. A larger National Health Institute-funded follow-up study is underway.
The current findings do not suggest a direct cause-and-effect relationship between the genetic changes and disease but highlight a potential biological pathway for further research.
“Just because you’re born with these markers doesn’t mean disease is inevitable,” Dr. Jowell said.
“But knowing your risk earlier in life could help families and clinicians take proactive steps to support a child’s long-term health.”
About this genetics and neurodevelopment research news
Author: Rachel Shubert
Source: Digestive Disease Week
Contact: Rachel Shubert – Digestive Disease Week
Image: The image is credited to Neuroscience News
Original Research: The findings will be presented at the Digestive Disease Week 2025 conference.
