A faster, more affordable way to produce quantum nanodiamonds holds promise for medicine and industry

The apparatus in which the luminescent nanodiamonds were prepared. Credit: Institute of Organic Chemistry and Biochemistry of the CAS

An international team of scientists from three continents led by Dr. Petr Cígler of IOCB Prague has developed a method for creating light-emitting quantum centers in nanodiamonds in only a matter of minutes. In just one week, the process can yield as much material as conventional methods would produce in more than forty years.

Moreover, the resulting nanodiamonds show improved optical and quantum properties. The breakthrough brings us one step closer to the industrial production of higher-quality and more affordable quantum nanodiamonds, which have broad applications in research and technology. The article is published in Advanced Functional Materials.

The research team has introduced a new procedure called Pressure and Temperature Qubits (PTQ), which takes only four minutes. Diamond powder is placed in a press that generates extremely high pressure and temperature, reproducing the conditions found deep within Earth’s mantle. Under these conditions, quantum centers are formed inside the nanodiamonds.






Credit: Institute of Organic Chemistry and Biochemistry of the CAS

To prevent the particles from fusing together, ordinary table salt is added. It melts during heating, creating a protective environment. After the process, the salt is simply removed with water, leaving a pure, luminescent material.

“We’ve accelerated the creation of quantum centers in nanodiamonds more than a thousandfold compared with the standard procedure. Until now, diamond powder had to be irradiated with a beam of charged particles for two weeks and then annealed at high temperature. The result was less than a gram of usable material. We can now produce it in kilograms,” says Dr. Michal Gulka, a postdoctoral researcher in Petr Cígler’s group and first author of the study.

Nanodiamonds are particles smaller than a virus that are used in advanced diagnostics to measure magnetic fields, charge, or temperature. They function as highly sensitive sensors thanks to a nitrogen-vacancy (NV) center—a nitrogen atom located next to a missing carbon atom in the diamond lattice. The NV center is fluorescent, meaning that when illuminated, it emits light. The intensity and timing of this light depend on changes in the surrounding environment, allowing nanodiamonds to detect even individual molecules or measure temperature inside cells.

IOCB Prague unveils a fundamentally faster, more affordable way to produce quantum nanodiamonds
The standard procedure for creating NV (nitrogen vacancy) quantum centers in nanodiamonds involves costly irradiation in particle accelerators and annealing. It is both laborious and time-consuming. The new method, which uses plastic deformation under extremely high temperature and pressure, produces both red-emitting NV centers and green-emitting H3 centers. Moreover, it repairs the diamond lattice, resulting in particles with a more stable charge state, higher magnetic resonance (MR) contrast, and improved spin properties of the NV centers, which enables more sensitive and accurate measurements. Credit: Institute of Organic Chemistry and Biochemistry of the CAS

A key contributor to the project is the American company MegaDiamond, which plans to launch industrial production of these nanosensors.

“Thanks to the new method, laboratories and companies around the world can obtain large quantities of high-quality nanodiamonds with NV centers, which opens the door to new technologies—from precision sensors for medical diagnostics to local molecular detectors based on principles such as magnetic resonance,” adds Dr. Cígler.

More information:
Yahua Bao et al, Quantum‐Grade Nanodiamonds from a Single‐Step, Industrial‐Scale Pressure and Temperature Process, Advanced Functional Materials (2025). DOI: 10.1002/adfm.202520907

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Institute of Organic Chemistry and Biochemistry of the CAS


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