Emotional Stress Triggers Instant Arousal From Deep Sleep

Summary: A new study uncovers a precise brain pathway that rapidly converts emotional stress into sudden wakefulness during NREM sleep. Researchers found that GABAergic neurons in the BNST activate glutamatergic…

Depression Quietly Damages the Heart Through Stress Circuits

Summary: Depression and anxiety may heighten cardiovascular disease risk through chronic stress pathways in the brain and body. In a large analysis of more than 85,000 adults, those with depression…

Stress Levels Predict Cannabis Use

Summary: New research shows that rats with naturally higher baseline stress hormone levels are significantly more likely to self-administer cannabis vapor. Over several weeks, rats were allowed to nose-poke for…

Anti-Inflammatory Treatments Show Promise for Depression

Summary: A new analysis shows that anti-inflammatory medications may help reduce symptoms for a subset of people with depression who also have chronic, low-grade inflammation. By reviewing randomized controlled trials…

PTSD Linked to Accelerated Brain Aging

Summary: A new study using advanced deep-learning brain age estimation shows that World Trade Center responders with PTSD exhibit signs of accelerated brain aging. Using BrainAgeNeXt, a model trained on…

Cognitive Profiles in Schizophrenia Are Being Ignored

Summary: A major scientific review reveals a deep knowledge gap in how cognition is affected when schizophrenia and personality disorders occur together. Despite the high prevalence and severe outcomes tied…

Abuse Survivors Show Unique Injury Signatures Tied to Suicide Risk

Summary: A new study finds that victims of intimate partner violence who also experience suicidal thoughts or behaviors show distinct and severe injury patterns on medical imaging. These patients were…

AI Uncovers Hidden Stress Damage in the Body

Summary: Researchers developed an AI tool that detects chronic stress by measuring adrenal gland volume on routine chest CT scans. This biomarker aligns with cortisol levels, stress questionnaires, and future…

Genetics Point to a New Type of Suicide Risk

Summary: New research shows that many people who die by suicide without prior suicidal thoughts or behaviors are not simply “missed cases”—they may have an entirely different underlying risk profile.…

Stress-Like Behaviors Traced to a Single ATP Circuit in the Brain

Summary: New research reveals that reduced ATP signaling in the hippocampus plays a causal role in both depression- and anxiety-like behaviors. In stressed male mice, ATP levels and the ATP-releasing…