Novel genomic screening tool enables precision reverse-engineering of genetic programming in cells

Schematic of Perturb-multiome’s biotinylation enrichment procedure to retrieve the identity of the sgRNA. Created in BioRender. Credit: Science (2025). DOI: 10.1126/science.ads7951 Collaborative research led by investigators at Dana-Farber/Boston Children’s Cancer…

Researchers combine 3D bioprinting with AI to personalize oral soft tissue grafts

The team from the National University of Singapore (NUS) utilises a 3D bioprinter to fabricate customised oral soft tissue grafts, integrating AI into the process, to optimise bioprinting parameters, enhance…

Exercise as an anti-aging intervention to avoid detrimental impact of mental fatigue

Credit: Monica Silvestre from Pexels Retired people who habitually exercise are more able to fight the impacts of mental fatigue, new research suggests. In a paper published in the Journal…

Pedometers suffice for measuring health-promoting physical activity, finds study

Credit: Journal of Internal Medicine (2025). DOI: 10.1111/joim.20081 A basic pedometer can prove sufficient for measuring health-promoting physical activity, according to a study comparing pedometers with more complex devices. Simply…

Is low BMI harmful in old age?

Associations of body mass index trajectories with all-cause mortality stratified by sex and baseline age for older Chinese adults from Hong Kong’s Elderly Health Service Cohort. Credit: Journal of Epidemiology…

Organoid model integrates microglia to study inflammation in brain

Pink skies. Microglia (magenta) integrated into a retinal organoid. The cell nuclei of neurons are stained in blue. Credit: Schmied et al. / Journal of Neuroinflammation Organoids have revolutionized science…

Study finds nearly five-fold increase in hospitalizations for common cause of stroke

Credit: CC0 Public Domain Cervical artery dissection is a tear in an artery in the neck that provides blood flow to the brain. Such a tear can result in blood…

Combination approach to advanced cancer could improve survival

Credit: Unsplash/CC0 Public Domain An international team of researchers, including experts from the University of Adelaide, has found genomic testing and targeted therapies for patients with advanced cancer could improve…

Low LDL cholesterol levels linked to reduced risk of dementia

Credit: CC0 Public Domain People with low levels of low-density lipoprotein cholesterol (LDL-C) in their blood have a lower risk of dementia, including lower risk of Alzheimer’s disease-related dementia, shows…

Rural communities need support to decrease health disparities and improve access to care, say researchers

Credit: Unsplash/CC0 Public Domain Rural communities in the United States face a dire health crisis that threatens the population’s well-being, says the American College of Physicians, in a new policy…