Summary: A new analysis of the PANDA clinical trial reveals that sertraline, one of the most prescribed antidepressants, improves key emotional symptoms of depression—such as sadness, self-loathing, and suicidal thoughts—within…
Tag: Antidepressants
Ketamine Fails to Outperform Placebo in Major Depression Trial
Summary: A large randomized and blinded clinical trial has found no additional benefit of repeated ketamine infusions over standard inpatient care for treating major depression. The study compared ketamine with…
EEG Test May Reveal Who Loses Libido on Antidepressants
Summary: A new study reveals that serotonin levels in the brain, measured using a simple EEG-based test, can predict who will experience sexual side effects from SSRI antidepressants. Researchers found…
Fat Molecule May Control How You Feel Emotion
Key Questions Answered Q: What did researchers discover about the serotonin 5-HT1A receptor?A: They mapped how it activates different brain signaling pathways, offering insight into how mood and emotion are…
How FDA panelists casting doubt on antidepressant use during pregnancy could lead to devastating outcomes for mothers
At a meeting held by the Food and Drug Administration on July 21, 2025, a panel convened by the agency cast doubt on the safety of antidepressant medications called selective…
How mothers supporting mothers can help fill the health care worker shortage gap and other barriers to care
For generations, women have relied on informal networks of friends, family and neighbors to navigate the complexities of birth and motherhood. Today, research is finally catching up to what generations…
Boosting Ketamine’s Antidepressant Effects to Last Two Months
Summary: Ketamine is a fast-acting antidepressant that can relieve symptoms of major depressive disorder (MDD) within hours, even in treatment-resistant cases. However, its effects typically last only a week, and…
Can Brain Scans Tell Which Antidepressant Will Work for You?
Summary: A new study shows that brain connectivity patterns, especially in the dorsal anterior cingulate cortex, can help predict how patients with major depressive disorder (MDD) will respond to antidepressants.…
How Psilocybin Lifts Mood Without the Hallucinogenic Trip
Summary: Researchers have uncovered two key brain mechanisms—specific neurons and a serotonin receptor—that help explain how psilocybin produces long-lasting antidepressant effects. Their study identified pyramidal tract neurons in the medial…
SSRIs May Speed Up Cognitive Decline
Summary: A new study based on data from 18,740 dementia patients suggests that antidepressants may accelerate cognitive decline. Researchers found that patients taking antidepressants, particularly SSRIs like escitalopram, citalopram, and…
