Summary: This week, research teams from around the globe shared their remarkable findings from the field of neuroscience. Discoveries ranged from unraveling how Botox breaches neurons, to a study finding…
Tag: Genetics
Gene Therapy Reverses Age-Related Hearing Loss
Summary: Researchers successfully demonstrated the efficacy of adeno-associated virus (AAV) vectors in reversing genetic hearing loss in aged animal models. The scientists developed a mature mouse model with a mutation…
Shared Genetics for Cannabis Use and Psychiatric Disorders
Summary: Researchers discovered shared genetic underpinnings for cannabis use and psychiatric disorders like schizophrenia and bipolar disorder. Employing advanced statistical modeling, the study revealed a complex interplay of genetic variants…
A proposed new metric to quantify genetic dissimilarities between an individual and a training population
Illustration of population-level versus individual-level PGS accuracy. a, Discrete labeling of GIA with PCA-based clustering. Each dot represents an individual. The circles represent arbitrary boundaries imposed on the genetic ancestry…
Researchers find link between obesity and blood cancer
Credit: Unsplash/CC0 Public Domain Indiana University School of Medicine researchers studying clonal hematopoiesis of indeterminate potential (CHIP), a blood condition that may increase the risk of blood cancer, discovered that…
Schizophrenia Risk Genes: Placenta’s Role May Outweigh Brain’s
Summary: In a paradigm shift, researchers found over 100 genes associated with schizophrenia risk operate primarily through their role in the placenta, rather than the developing brain. The research emphasizes…
DNA project gives scientists diverse genome for comparison
Credit: CC0 Public Domain For two decades, scientists have been comparing every person’s full set of DNA they study to a template that relies mostly on genetic material from one…
Cellular ‘cruise control’ system safeguards RNA levels in Rett syndrome nerve cells
Cis-acting elements in the 3ʹUTR are highly associated with half-life changes. a Random forest classifier for prediction of mRNA sequence features relevant for half-life fold-change in human NEURTT and in…
Stress Rapidly Increases Biological Age, but Recovery Turns Back the Clock
Summary: Stress can cause rapid and transient increases in biological age, which can be reversed upon recovery, according to a new study. Using DNA methylation clocks, researchers found that stress…
Preclinical promise and the unveiling of a prognostic gene signature
Omomyc induces growth arrest in melanoma human cell lines in vitro. (A) Growth inhibition by transgenic Omomyc at 10 d by Crystal Violet staining. (B) Early effect of Omomyc on…
