Modulation of tau expression in C57BL/6 mice retinas. Credit: Acta Neuropathologica Communications (2024). DOI: 10.1186/s40478-024-01804-0 The protein tau is essential to the function of cells in the brain and central…
Tag: Genetics
Adjusting Proteins Increases Ozempic’s Effectiveness
Summary: Adjusting melanocortin proteins in the brain enhances the effectiveness of GLP-1 diabetes and weight-loss drugs. By inhibiting MC3R or activating MC4R, mice showed increased sensitivity to these drugs, leading…
Study Reveals Structure of Alzheimer’s Molecules in Human Brain
Summary: In a groundbreaking study, scientists have determined the structure of molecules within a human brain affected by Alzheimer’s disease. Using cryo-electron tomography and fluorescence microscopy, researchers created 3D maps…
Researchers map the effects of all potential changes in key cancer gene
Function scores capture fitness effects mediated at both the transcript and protein 457 level. Credit: Megan Buckley et al Researchers at the Francis Crick Institute have mapped all the possible…
Oxytocin’s Link to Obesity and Postnatal Depression
Summary: A new study has identified the TRPC5 gene as a cause of obesity, behavioral issues, and postnatal depression. Researchers found that missing or impaired TRPC5 genes disrupt oxytocin neurons,…
Kidneys from Black donors are more likely to be thrown away − a bioethicist explains why
As one of the leading causes of death in the U.S., kidney disease is a serious public health problem. The disease is particularly severe among Black Americans, who are three…
Genetic testing cannot reveal the gender of your baby − two genetic counselors explain the complexities of sex and gender
Gender reveal parties are best known as celebrations involving pink and blue, cake and confetti, and the occasional wildfire. Along with being social media hits, gender reveals are a testament…
Study uncovers multiple molecular subgroups in liver cancer with most aggressive driving clinical outcomes
Credit: Journal of Hepatology (2024). DOI: 10.1016/j.jhep.2024.05.017 A study led by clinician-scientists and scientists from the National Cancer Centre Singapore (NCCS) and A*STAR’s Genome Institute of Singapore (GIS) has discovered…
Learning and Memory Formation’s Molecular Basis
Summary: Researchers developed a new platform to explore dendritic translation’s role in memory formation and its implications for intellectual disorders. By employing a novel method named TurboID, researchers uncovered a…
