Summary: Schizophrenia treatment has been dominated by dopamine-targeting drugs for decades, but these often fail to address the debilitating cognitive and negative symptoms of the disorder. A comprehensive review synthesizes…
Tag: Dopamine
Less Experience Leads to Faster Neural Adaptation
Summary: For over a century, the cornerstone of psychology has been the Pavlovian idea that we learn through repetition—the more a bell rings before food, the stronger the association. However,…
Thrill Fatigue: How Dopamine Devalues Repeated Rewards
Summary: New research shows that the same dopamine receptor mechanism responsible for drug addiction also governs the natural decline in motivation when we repeat rewarding behaviors. By studying male fruit…
Dopamine Boost Makes People More Patient
Summary: In one of the largest studies of its kind, researchers found that increasing dopamine levels with L-DOPA made people slightly more willing to wait for larger, delayed rewards—reducing impulsive…
Boosting Prefrontal Dopamine Shows Promise in Cutting Alcohol Use
Summary: A new study reveals that tolcapone, a dopamine-enhancing drug, strengthens brain circuits involved in self-control while reducing alcohol intake in people with alcohol use disorder (AUD). The drug boosts…
Flavored Vapes Trigger Reward Centers Even Without Nicotine
Summary: A new study shows that some e-cigarette flavorings, like vanilla and cherry, can trigger reward-seeking behaviors in adolescent mice even without nicotine. Researchers found that these flavors alone could…
More Than Serotonin: How Psychedelics Engage the Whole Brain
Summary: Classical psychedelics like LSD, psilocybin, and mescaline are known for activating the 5-HT2A serotonin receptor, but a new study reveals their effects go far beyond. Researchers profiled 41 psychedelics…
Low Sodium Linked to Anxiety Through Brain Chemistry Disruption
Summary: Chronic hyponatremia—long viewed as symptomless—is now shown to disrupt brain chemistry and cause anxiety-like behaviors, according to a new study in mice. Researchers found that prolonged low sodium levels…
Shared Genetic Signatures Found Across Psychiatric Disorders
Summary: Researchers have uncovered shared biological mechanisms across major psychiatric disorders by analyzing postmortem brain samples from the dorsolateral prefrontal cortex. Instead of looking at gene expression broadly, they zoomed…
Vitamin B1 Derivative Sparks Dopamine, Boosts Wakefulness
Summary: Thiamine derivatives, once developed to treat nutrient deficiencies, are now being explored for their potential effects on brain function and energy. A new study shows that TTFD, a thiamine…
