Have you ever wondered why certain medications don’t seem to work as well for you as they do for others? This variability in drug response is what pharmacogenomic testing hopes…
Tag: Genetics
Study links epigenetic changes to historic trauma in Alaska Native communities
The study team included, from left, Alida de Flamingh, Rosita Worl, Alyssa Bader, Ripan Malhi, Chuck Smythe, Mary LaVanne and Mason Auger. Credit: Sealaska Heritage Institute Researchers investigated the relationship…
Gene-tweaked stem cells offer hope against sickle cell disease
A type of gene therapy that precisely “edits” a key bit of DNA might offer a new way to treat sickle cell disease—a painful inherited condition that largely strikes Black…
Study findings provide new insight into how breast cancer evolves
The der(1;16) translocation-positive breast cancer originated from a single cell around puberty. This cell repeatedly underwent cell division and expanded until it developed into breast cancer several decades later. Then,…
Gene Mutation Sheds Light on Schizophrenia Mysteries
Summary: Scientists developed a mouse model that carries a genetic mutation linked to an increased risk of schizophrenia. By studying the Grin2a gene, they found significant changes in gene expression,…
Schizophrenia gene mutation causes many changes in the mouse brain, new study shows
Researchers studied the effects of a schizophrenia gene mutation in different regions of the mouse brain. Credit: Susanna Hamilton, Broad Communications Researchers have identified common and rare gene mutations that…
Genes Behind Depression Could Pave Way for Other Mental Disorders
Summary: Researchers completed the largest-ever genetic study on depression, encompassing 1.3 million genomes. Their findings indicate that individuals with hospital-treated depression have an increased genetic risk for other psychiatric conditions…
Research team completes long-anticipated genome sequencing of Y chromosome
Researchers have filled in the final pieces of the puzzle for mapping a complete Y chromosome in humans. Credit: N. Hanacek/NIST Twenty years ago, when researchers from the Human Genome…
Scientists discover mutations in blood stem cells can exacerbate colon cancer
Compared with normal mice (top), colonoscopies detect more, and larger, tumors in the intestines of mice with clonal hematopoiesis (bottom). Credit: © 2023 Feng et al. Originally published in Journal…
Unlocking Schizophrenia: Mitochondria Dysfunction at the Forefront
Summary: Researchers have identified a pivotal role of impaired mitochondrial function in the development of schizophrenia by examining the genetic risk factor 3q29 deletion syndrome. The genetic condition, known to…
