Summary: A new study has shown that conscious thought relies on synchronized brain rhythms to maintain communication between sensory and cognitive brain regions. Under general anesthesia, this rhythm-based communication breaks…
Tag: neuropharmacology
Dual-Targeting Drug Halts Tau Accumulation in Alzheimer’s
Summary: Scientists have developed a drug that targets both major aggregation-promoting sites of the Tau protein, a key player in Alzheimer’s disease. This peptide inhibitor, RI-AG03, effectively prevents Tau buildup…
Alzheimer’s Drug Faces Scrutiny Over Safety, Efficacy Concerns
Summary: The FDA-approved Alzheimer’s drug donanemab is under scrutiny due to concerns about its effectiveness and safety, according to an investigation. The study highlights multiple patient deaths during trials, design…
No Link Found Between Ozempic and Suicide Risk
Summary: A new study has found no evidence that GLP-1 analogues, common diabetes drugs, increase the risk of suicide, self-harm, or related mental health issues. Researchers analyzed data from around…
Morphine’s Pain Relief Mechanism Unveiled
Summary: Researchers have uncovered how morphine relieves pain by activating a specific group of neurons in the brain, termed the ‘morphine ensemble.’ These neurons, located in the rostral ventromedial medulla…
Adjusting Proteins Increases Ozempic’s Effectiveness
Summary: Adjusting melanocortin proteins in the brain enhances the effectiveness of GLP-1 diabetes and weight-loss drugs. By inhibiting MC3R or activating MC4R, mice showed increased sensitivity to these drugs, leading…
Immunotherapy Shows Promise as Alzheimer’s Treatment
Summary: Researchers unveiled a novel approach to combat Alzheimer’s disease by activating microglia, the brain’s immune cells, to devour amyloid beta plaques, a hallmark of the condition. This study highlights…
Compound May Curb Alcohol Dependence
Summary: The compound LY2444296, which blocks the kappa opioid receptor, significantly reduces alcohol consumption in animal models of alcohol dependence. This study suggests LY2444296 could be a breakthrough in treating…
CaMKII Can Be Regulated to Mitigate Alzheimer’s
Summary: The CaMKII protein, critical in brain and heart function, can be regulated to mitigate Alzheimer’s and heart conditions using three types of drug inhibitors. Their findings reveal that these…
Long-term Acid Reflux Drugs Linked to Higher Dementia Risk?
Summary: Long-term use (over 4.4 years) of proton pump inhibitors, prescribed for acid reflux, may be associated with an increased risk of dementia. However, this research does not establish a…
