Summary: Researchers introduce “apical hypercontextualisation”—a bottom-up neurobiological mechanism explaining how psychedelics (psilocybin, LSD, DMT, mescaline) transform perception and cognition. Moving beyond macro-scale whole-brain neuroimaging, the framework focuses on the cellular…
Tag: Psychedelics
Psychedelics and Ketamine Rewire Brain Immune Signals in Depression
Summary: A study uncovered a novel neuroimmune mechanism explaining how rapid-acting antidepressants, including ketamine and psychedelics, alleviate treatment-resistant depression. Despite acting on different initial neural receptors, these distinct fast-acting therapeutics…
Psilocybin Therapy Drives 75% PTSD Remission
Summary: The first U.S. clinical trial evaluating psilocybin-assisted therapy in military veterans with treatment-resistant post-traumatic stress disorder (PTSD) has demonstrated significant safety and clinical efficacy. The 11-week pilot trial combined…
Psychedelic Trips Can Halt Political Hate
Summary: A massive study tracking 21,990 U.S. adults has demonstrated that the specific cultural and political atmosphere surrounding a psychedelic experience can systematically pivot its psychological aftermath. Participants whose most…
Single Psilocybin Dose Sparks Rapid Depression Remission
Summary: A Phase 2 randomized clinical trial demonstrates that a single 25 mg dose of psilocybin, combined with psychotherapeutic support, provides rapid, statistically significant, and clinically meaningful reduction in symptoms…
Psychedelics Remodel Myelin to Heal PTSD
Summary: For years, scientists have focused on how psychedelics “rewire” neurons. But a groundbreaking study has found a “missing link” in long-term PTSD recovery: myelin remodeling. Researchers discovered that psilocybin…
Single DMT Dose Provides Lasting Relief from Depression
Summary: While psychedelic research often focuses on hours-long “trips” with psilocybin or LSD, a landmark Phase IIa trial has proven that a much shorter experience can be just as potent.…
Psychedelic ‘Ego Death’ Tied to a Collapse in Alpha Brain Waves
Summary: A new study using DMT as a scientific tool reveals how psychedelics alter the brain’s alpha-wave dynamics and weaken our sense of self. The researchers found that DMT pushes…
Psilocybin Rewire Brain Circuits Tied to Pain and Mood
Summary: New research shows that psilocybin, the active compound in psychedelic mushrooms, can reduce both chronic pain and pain-related depression by modulating brain circuits rather than acting at the site…
Why religious groups are pushing for psychedelics as sacrament
Texas passed a landmark law in June 2025, supported by former Gov. Rick Perry, that allocates US$50 million to support research on ibogaine, one of the most powerful psychedelics, for…
