Astrocyte Disruption Tied to Depression After Childhood Stress

Summary: Researchers have shown that astrocytes in the lateral hypothalamus play a pivotal role in how stress shapes behavior, particularly after early-life adversity. In mice, stress led to smaller, less…

Sex Shapes the Course of Bipolar Disorder and Schizophrenia

Summary: A large multicenter study has revealed that sex influences the course and characteristics of schizophrenia and bipolar disorder. Women with schizophrenia tended to begin treatment later, while men with…

Chronic Stress Sends Immune Cells to Brain, Driving Depression

Summary: A new study shows that chronic stress causes immune cells called neutrophils to leave bone marrow in the skull and collect in the brain’s protective membranes, where they contribute…

Depression Disrupts Learning to Avoid Unpleasant Events

Summary: Depression specifically impairs the ability to learn how to actively avoid unpleasant events, though it does not affect avoidance behavior once learned. Researchers tested 465 participants across a range…

Hormonal Contraceptives Influence Memory of Emotional Events

Summary: A new study reveals that hormonal contraceptives may shape both emotional responses and memory processing in women. Compared with naturally cycling women, users of hormonal birth control had stronger…

Brain Cells Behind Depression Identified

Summary: Researchers analyzing post-mortem brain tissue found two cell types altered in people with depression: excitatory neurons that regulate mood and stress, and microglia that manage inflammation. The findings highlight…

The Midlife “Unhappiness Hump” Has Vanished, But at a Cost

Summary: A new large-scale study finds that the long-observed “unhappiness hump,” where mental distress peaked in midlife, has disappeared. Instead, younger people now report the highest levels of anxiety, depression,…

Cannabis Linked to Reduced Insomnia and Anxiety

Summary: A new study suggests cannabis-based medical products may help people with insomnia sleep better over the long term. Across 124 patients followed for up to 18 months, participants consistently…

Big Five No More? New Study Uncovers Hidden Personality Traits

Summary: For 40 years, the Big Five personality model has dominated psychology, but new research suggests it may be incomplete. Using taxonomic graph analysis, researchers mapped personality from the ground…

High-THC Cannabis Linked to Psychosis and Addiction

Summary: A systematic review of nearly 100 studies found that high-THC cannabis products are linked to negative mental health outcomes, particularly psychosis, schizophrenia, and cannabis use disorder. While some therapeutic…