New insights into the protein-mediated motor neuron loss in amyotrophic lateral sclerosis

Using novel mouse ALS models, researchers discovered that the pathogenic TDP-43 exhibits distinct propagation patterns in the corticospinal pathway and spinal circuits, providing insights into the mechanisms underlying the progressive…

Research identifies gene ‘fingerprint’ for brain aging

Graphical abstract. Credit: Cell (2023). DOI: 10.1016/j.cell.2023.07.027 Most of us who’ve reached middle age have noticed a slowing in memory and cognition, but scientists don’t have a clear picture of…

What to know about meningioma and glioblastoma brain tumors

Credit: Unsplash/CC0 Public Domain A diagnosis of a brain tumor can be frightening. Of the more than 100 types of brain tumors, meningioma and glioblastoma are two of the most…

How our tastes influence our creativity

Abstract representation of creativity. Credit: Paris Brain Institute The more we like our ideas, the faster we give them shape. But to be creative, we need to focus on out-of-the-box…

Attention is required for a popular brain signature of prediction error, researchers find

(A) Event-related potentials and (B) difference waves from various electrode clusters. The arrows highlight a possible alternative marker of pre-attentive error detection in the visual system—early deviant related positivity (EDRP).…

AI Pinpoints Parkinson’s Subtypes Using Stem Cell Images

Summary: Researchers enabled machine learning to accurately predict Parkinson’s disease subtypes using stem cell images. This breakthrough showcases computer models classifying four Parkinson’s subtypes, with top accuracies reaching 95%. This…

Brain’s ‘Traffic Directors’: Neurons That Keep Us Focused on Tasks

Summary: Researchers have illuminated how our brain maintains focus amidst distractions. Their study identifies “visual-movement” neurons in the lateral prefrontal cortex (LPFC) that use coordinated activity called “beta bursts” to…

Baby Gut Microbes: A Link to Early Cognitive Skills?

Summary: Researchers discovered associations between specific microbes in infants’ guts and early cognitive development performance. This exploratory study examined 56 infants, revealing that certain microbiome compositions corresponded with success in…

Long-term Acid Reflux Drugs Linked to Higher Dementia Risk?

Summary: Long-term use (over 4.4 years) of proton pump inhibitors, prescribed for acid reflux, may be associated with an increased risk of dementia. However, this research does not establish a…

Dopamine Tunes the Brain for Both Singing and Speech

Summary: Contrary to popular belief, speech and singing use overlapping brain circuits, primarily located in the left hemisphere. This discovery challenges the 50-year notion that the right hemisphere supports the…